Review Sheet Exercise 13 Neuron Anatomy And Physiology.43
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All these different structures have been generated in different environments and determined by different techniques. The special form of Aβ structures may be not stable or may be stabilized only in a unique solution; they may be similar but not the same as each other; one structure may depict one representative form of Aβ, and all the forms of Aβ may co-exist in vivo. Aβ forms a myriad of structures in the monomeric and oligomeric states, all of which result in similar fibril structures. Amyloid fibrils of Aβ form a parallel, in-register cross β-sheet structure. The accumulation of Aβ into long, unbranched fibrils is a hallmark of the disease, as is the loss of neurons due to cell death in parallel with the Aβ aggregation process. These new insights into the structures and aggregation pathways may help to uncover the mechanisms of amyloid pathogenesis in degenerative diseases, ultimately leading to new therapeutic strategies to prevent the formation of toxic aggregates (Table 1). 153554b96e
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